![Modeling of hinge-hinge interactions. The extracellular part of the... | Download Scientific Diagram Modeling of hinge-hinge interactions. The extracellular part of the... | Download Scientific Diagram](https://www.researchgate.net/publication/350312605/figure/fig6/AS:1004418698854401@1616483487011/Modeling-of-hinge-hinge-interactions-The-extracellular-part-of-the-CD28-receptor-and.png)
Modeling of hinge-hinge interactions. The extracellular part of the... | Download Scientific Diagram
![Chimeric Antigen Receptor T Cells and Hematopoietic Cell Transplantation: How Not to Put the CART Before the Horse - Biology of Blood and Marrow Transplantation Chimeric Antigen Receptor T Cells and Hematopoietic Cell Transplantation: How Not to Put the CART Before the Horse - Biology of Blood and Marrow Transplantation](https://www.astctjournal.org/cms/attachment/3666e339-3f5c-432a-97cf-6c3215031679/ybbmt54386-fig-0001_lrg.jpg)
Chimeric Antigen Receptor T Cells and Hematopoietic Cell Transplantation: How Not to Put the CART Before the Horse - Biology of Blood and Marrow Transplantation
![Frontiers | The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28 Frontiers | The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28](https://www.frontiersin.org/files/Articles/639818/fimmu-12-639818-HTML-r1/image_m/fimmu-12-639818-g001.jpg)
Frontiers | The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28
Function of Novel Anti-CD19 Chimeric Antigen Receptors with Human Variable Regions Is Affected by Hinge and Transmembrane Domain
![Cancers | Free Full-Text | Engineering Solutions for Mitigation of Chimeric Antigen Receptor T-Cell Dysfunction Cancers | Free Full-Text | Engineering Solutions for Mitigation of Chimeric Antigen Receptor T-Cell Dysfunction](https://www.mdpi.com/cancers/cancers-12-02326/article_deploy/html/images/cancers-12-02326-g001.png)
Cancers | Free Full-Text | Engineering Solutions for Mitigation of Chimeric Antigen Receptor T-Cell Dysfunction
![Two Families of Hinges IgG-based hinges, derived from IgG1, IgG2, or... | Download Scientific Diagram Two Families of Hinges IgG-based hinges, derived from IgG1, IgG2, or... | Download Scientific Diagram](https://www.researchgate.net/publication/330030483/figure/fig1/AS:718035467923461@1548204404193/Two-Families-of-Hinges-IgG-based-hinges-derived-from-IgG1-IgG2-or-IgG4-provide.png)
Two Families of Hinges IgG-based hinges, derived from IgG1, IgG2, or... | Download Scientific Diagram
![Activity of sCAR hinge designs. (A) Cytotoxicity of sCAR-T cells with... | Download Scientific Diagram Activity of sCAR hinge designs. (A) Cytotoxicity of sCAR-T cells with... | Download Scientific Diagram](https://www.researchgate.net/publication/290431851/figure/fig5/AS:668645776687116@1536428984869/Activity-of-sCAR-hinge-designs-A-Cytotoxicity-of-sCAR-T-cells-with-CD8-IgG4-or-IgG4m.png)
Activity of sCAR hinge designs. (A) Cytotoxicity of sCAR-T cells with... | Download Scientific Diagram
![Crystals | Free Full-Text | Crystal Structure of a Chimeric Antigen Receptor (CAR) scFv Domain Rearrangement Forming a VL-VL Dimer Crystals | Free Full-Text | Crystal Structure of a Chimeric Antigen Receptor (CAR) scFv Domain Rearrangement Forming a VL-VL Dimer](https://www.mdpi.com/crystals/crystals-13-00710/article_deploy/html/images/crystals-13-00710-g001.png)
Crystals | Free Full-Text | Crystal Structure of a Chimeric Antigen Receptor (CAR) scFv Domain Rearrangement Forming a VL-VL Dimer
![The IgG4 hinge with CD28 transmembrane domain improves VHH-based CAR T cells targeting a membrane-distal epitope of GPC1 in pancreatic cancer | Nature Communications The IgG4 hinge with CD28 transmembrane domain improves VHH-based CAR T cells targeting a membrane-distal epitope of GPC1 in pancreatic cancer | Nature Communications](https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-023-37616-4/MediaObjects/41467_2023_37616_Fig3_HTML.png)
The IgG4 hinge with CD28 transmembrane domain improves VHH-based CAR T cells targeting a membrane-distal epitope of GPC1 in pancreatic cancer | Nature Communications
![CD8 Binding of MHC-Peptide Complexes in cis or trans Regulates CD8+ T-cell Responses - ScienceDirect CD8 Binding of MHC-Peptide Complexes in cis or trans Regulates CD8+ T-cell Responses - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0022283619306151-fx1.jpg)
CD8 Binding of MHC-Peptide Complexes in cis or trans Regulates CD8+ T-cell Responses - ScienceDirect
![Engineering strategies to overcome the current roadblocks in CAR T cell therapy | Nature Reviews Clinical Oncology Engineering strategies to overcome the current roadblocks in CAR T cell therapy | Nature Reviews Clinical Oncology](https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41571-019-0297-y/MediaObjects/41571_2019_297_Fig1_HTML.png)
Engineering strategies to overcome the current roadblocks in CAR T cell therapy | Nature Reviews Clinical Oncology
Hinge and Transmembrane Domains of Chimeric Antigen Receptor Regulate Receptor Expression and Signaling Threshold
![The CD8α hinge is intrinsically disordered with a dynamic exchange that includes proline cis-trans isomerization - ScienceDirect The CD8α hinge is intrinsically disordered with a dynamic exchange that includes proline cis-trans isomerization - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S1090780722000921-gr1.jpg)
The CD8α hinge is intrinsically disordered with a dynamic exchange that includes proline cis-trans isomerization - ScienceDirect
![Cells | Free Full-Text | Hinge and Transmembrane Domains of Chimeric Antigen Receptor Regulate Receptor Expression and Signaling Threshold Cells | Free Full-Text | Hinge and Transmembrane Domains of Chimeric Antigen Receptor Regulate Receptor Expression and Signaling Threshold](https://pub.mdpi-res.com/cells/cells-09-01182/article_deploy/html/images/cells-09-01182-g005a.png?1589017728)
Cells | Free Full-Text | Hinge and Transmembrane Domains of Chimeric Antigen Receptor Regulate Receptor Expression and Signaling Threshold
![JCI Insight - Sensitive and adaptable pharmacological control of CAR T cells through extracellular receptor dimerization JCI Insight - Sensitive and adaptable pharmacological control of CAR T cells through extracellular receptor dimerization](https://df6sxcketz7bb.cloudfront.net/manuscripts/124000/124430/medium/jci.insight.124430.ga.jpg)
JCI Insight - Sensitive and adaptable pharmacological control of CAR T cells through extracellular receptor dimerization
![The CD8α hinge is intrinsically disordered with a dynamic exchange that includes proline cis-trans isomerization - ScienceDirect The CD8α hinge is intrinsically disordered with a dynamic exchange that includes proline cis-trans isomerization - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S1090780722000921-ga1.jpg)
The CD8α hinge is intrinsically disordered with a dynamic exchange that includes proline cis-trans isomerization - ScienceDirect
![Antigenic Sensitivity of Membrane-Proximal Targeting Chimeric Antigen Receptors can be Fine-Tuned through Hinge Truncation | bioRxiv Antigenic Sensitivity of Membrane-Proximal Targeting Chimeric Antigen Receptors can be Fine-Tuned through Hinge Truncation | bioRxiv](https://www.biorxiv.org/content/biorxiv/early/2021/05/03/2020.10.30.360925/F1.large.jpg)
Antigenic Sensitivity of Membrane-Proximal Targeting Chimeric Antigen Receptors can be Fine-Tuned through Hinge Truncation | bioRxiv
![Incorporation of a hinge domain improves the expansion of chimeric antigen receptor T cells | Journal of Hematology & Oncology | Full Text Incorporation of a hinge domain improves the expansion of chimeric antigen receptor T cells | Journal of Hematology & Oncology | Full Text](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs13045-017-0437-8/MediaObjects/13045_2017_437_Fig2_HTML.gif)
Incorporation of a hinge domain improves the expansion of chimeric antigen receptor T cells | Journal of Hematology & Oncology | Full Text
![Cells | Free Full-Text | Hinge and Transmembrane Domains of Chimeric Antigen Receptor Regulate Receptor Expression and Signaling Threshold Cells | Free Full-Text | Hinge and Transmembrane Domains of Chimeric Antigen Receptor Regulate Receptor Expression and Signaling Threshold](https://www.mdpi.com/cells/cells-09-01182/article_deploy/html/images/cells-09-01182-g001b.png)